Preliminary studies on streptomutin A

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Summary

Supplementation of the culture medium with 2-deoxystreptidine allowsStreptomyces griseus MIT-5, an idiotrophic mutant, to produce an antibiotic which we have called streptomutin A. Degradation studies on the antibiotic showed that the aminocyclitol moiety is different from streptidine. Streptomutin A also is distinct from streptomycin in having a much different ratio of biological to chemical activity.

This paper is Contribution No. 2746 from the Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, U.S.A.