Zeitschrift für Parasitenkunde

, Volume 63, Issue 2, pp 113–128

Light and electron microscopic studies on the effect of praziquantel onSchistosoma mansoni, Dicrocoelium dendriticum, andFasciola hepatica (trematoda) in vitro

Authors

  • B. Becker
    • Institut für Zoologie II der Universität Düsseldorf
  • H. Mehlhorn
    • Institut für Zoologie II der Universität Düsseldorf
  • P. Andrews
    • Bayer Pharma-ForschungszentrumInstitut für Chemotherapie
  • H. Thomas
    • Bayer Pharma-ForschungszentrumInstitut für Chemotherapie
  • J. Eckert
    • Institut für Parasitologie der Universität Zürich
Original Investigations

DOI: 10.1007/BF00927527

Cite this article as:
Becker, B., Mehlhorn, H., Andrews, P. et al. Z. Parasitenkd. (1980) 63: 113. doi:10.1007/BF00927527

Abstract

The fine structure of the tegument of three trematode species,Schistosoma mansoni, Dicrocoelium dendriticum, andFasciola hepatica, was studied by means of light scanning (SEM) and transmission electron microscopy (TEM) after in vitro exposure to 0, 1,10, and 100 μg/ml of the anthelmintic praziquantel for 5, 15, 30, and 60 min. InS. mansoni andD. dendriticum the resulting vacuolization of the tegument was confined to numerous small areas scattered all over the surface of the parasites and this finally led to the disruption of the apical tegumental layer. No changes were found in the tegument ofF. hepatica after treatment with praziquantel.

Key words

Schistosoma mansoni Dicrocoelium dendriticum Fasciola hepatica Praziquantel Fine structure Tegument

Abbreviations

B

Bubbles

BL

Basement layer

CM

Circular musculature

GA

Genital atrium

GC

Gynaecophoric canal

IB

Inclusion bodies

IM

Interstitial material

LM

Longitudinal musculature

MI

Mitochondria

OS

Oral sucker

R

Ridges

S

Spine

SP

Surface pits

T

Tubercle

TG

Tegument

V

Vacuoles

VS

Ventral sucker

SEM

Scanning electron microscopy

TEM

Transmission electron microscopy

Copyright information

© Springer-Verlag 1980