Zeitschrift für Parasitenkunde

, Volume 69, Issue 5, pp 577–581

The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronicT. brucei infections in mice

  • F. W. Jennings
  • G. M. Urquhart
Original Investigations

DOI: 10.1007/BF00926669

Cite this article as:
Jennings, F.W. & Urquhart, G.M. Z. Parasitenkd. (1983) 69: 577. doi:10.1007/BF00926669


Relapse of chronicT. brucei infections was completely prevented by treating with either diminazene aceturate (Berenil) at 40 mg/kg or suramin (Germanin) at 20mg/kg followed by four doses of the 2-substituted 5-nitroimidazole (Fexinidazole)(Hoe 239). None of these drugs administered singly elicited 100% permanent cures although a high percentage of the mice were cured with four doses of Fexinidazole at 250 mg/kg.

A single dose of 20 mg/kg suramin followed by four daily doses of 30 mg/kg Fexinidazole will effectively eliminate all the trypanosomes from the brains of chronically infected mice.

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • F. W. Jennings
    • 1
  • G. M. Urquhart
    • 1
  1. 1.Department of Veterinary ParasitologyUniversity of GlasgowGlasgowUK