The use of the 2 substituted 5-nitroimidazole, fexinidazole (Hoe 239) in the treatment of chronicT. brucei infections in mice
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- Jennings, F.W. & Urquhart, G.M. Z. Parasitenkd. (1983) 69: 577. doi:10.1007/BF00926669
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Relapse of chronicT. brucei infections was completely prevented by treating with either diminazene aceturate (Berenil) at 40 mg/kg or suramin (Germanin) at 20mg/kg followed by four doses of the 2-substituted 5-nitroimidazole (Fexinidazole)(Hoe 239). None of these drugs administered singly elicited 100% permanent cures although a high percentage of the mice were cured with four doses of Fexinidazole at 250 mg/kg.
A single dose of 20 mg/kg suramin followed by four daily doses of 30 mg/kg Fexinidazole will effectively eliminate all the trypanosomes from the brains of chronically infected mice.