Original Articles

Journal of Clinical Immunology

, Volume 12, Issue 4, pp 259-265

Conjunctival epithelial cells from patients with Sjögren's syndrome inappropriately express major histocompatibility complex molecules, La(SSB) antigen, and heat-shock proteins

  • Dimitri I. YannopoulosAffiliated withLaboratory of Immunology, Brest University Medical School Hospital
  • , Stéphane RoncinAffiliated withUnit of Ophthalmology, Brest University Medical School
  • , Armelle LamourAffiliated withLaboratory of Immunology, Brest University Medical School Hospital
  • , Yvon L. PennecAffiliated withDepartment of Internal Medicine, Brest University Medical School
  • , Haralampos M. MoutsopoulosAffiliated withLaboratory of Immunology, Brest University Medical School Hospital
  • , Pierre YouinouAffiliated withLaboratory of Immunology, Brest University Medical School Hospital

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Abstract

The La(SSB) antigen has been detected within the cytoplasm and on the membrane of conjunctival cells (CC) from patients with Sjögren's syndrome, whereas it was weakly expressed in the nucleus of normal cells. The diseased CC were shown to overproduce major histocompatibility complex (MHC) class I antigens and express MHC class II antigens. Anti-heat-shock protein monoclonal antibody bound to the cell membrane in patients but not in normal controls.

Key words

Sjögren's syndrome La(SSB) antigen epithelial cells