Journal of Clinical Immunology

, Volume 8, Issue 6, pp 447–452

Increased serum levels of soluble interleukin-2 receptor in patients with systemic lupus erythematosus and rheumatoid arthritis

Authors

  • G. Semenzato
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • L. M. Bambara
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • D. Biasi
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • A. Frigo
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • F. Vinante
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • B. Zuppini
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • L. Trentin
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • C. Feruglio
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • M. Chilosi
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
  • G. Pizzolo
    • Department of Clinical Medicine, First Medical Clinic and Clinical Immunology BranchPadua University School of Medicine
    • Departments of Medical Pathology, Hematology, and PathologyVerona University School of Medicine
Original Articles

DOI: 10.1007/BF00916949

Cite this article as:
Semenzato, G., Bambara, L.M., Biasi, D. et al. J Clin Immunol (1988) 8: 447. doi:10.1007/BF00916949

Abstract

In this study we investigated the serum levels of a released soluble form of the interleukin-2 receptor (sIL-2R) in 42 patients with rheumatoid arthritis and in 12 cases of systemic lupus erythematosus. Data were evaluated in relationship to the clinical phase and compared with those observed in normal controls (N=56) and in osteoarthritis (N = 7). Increased levels were observed in both rheumatoid arthritis (mean ± SE, 604±49 U/ml) and systemic lupus erythematosus (1438±481 U/ml). These values were significantly higher than in control (256±15 U/ml;P<0.001) and in osteoarthritis (298±33 U/ml;P<0.001) groups. In addition, the highest values were associated with the active phases of both rheumatoid arthritis (active vs inactive, 771±78 vs 451±39 U/ml;P<0.001) and systemic lupus erythematosus (active vs inactive, 2108±489 vs 499±75 U/ml;P<0.001). Our findings suggest that the detection of sIL-2R in rheumatoid arthritis and in systemic lupus erythematosus may represent a good marker of disease activity, which indirectly indicates the ongoing activation and/or proliferation of immunoreactive cells which are involved in the pathogenetic events of these autoimmune conditions.

Key words

Soluble interleukin-2 receptorsystemic lupus erythematosusrheumatoid arthritis

Copyright information

© Plenum Publishing Corporation 1988