Inflammation

, Volume 10, Issue 4, pp 387–392

Effects of dietary fish oil supplementation on polymorphonuclear leukocyte inflammatory potential

  • Marc Fisher
  • Katherine S. Upchurch
  • Peter H. Levine
  • Mark H. Johnson
  • Christine H. Vaudreuil
  • Anita Natale
  • James J. Hoogasian
Original Articles

DOI: 10.1007/BF00915822

Cite this article as:
Fisher, M., Upchurch, K.S., Levine, P.H. et al. Inflammation (1986) 10: 387. doi:10.1007/BF00915822

Abstract

Polymorphonuclear leukocytes (PMNLs) are an important contributor to inflammation and are thus a part of the pathophysiology of many human diseases. We assessed the effect of fish oil on PMNL inflammatory potential by measuring chemiluminescence and Superoxide production before and after six weeks of daily cod liver oil ingestion by healthy volunteers. Phagocytosing PMNLs demonstrated a 27% decrease in chemiluminescence (P < 0.05) and a 64% decrease in Superoxide production (P < 0.01), following the cod liver oil supplementation. Analysis of PMNL and platelet fatty acids revealed the appearance of eicosapentaenoic acid and a significant decrease in arachidonic acid in both types of cells.

Copyright information

© Plenum Publishing Corporation 1986

Authors and Affiliations

  • Marc Fisher
    • 1
    • 2
    • 3
  • Katherine S. Upchurch
    • 1
    • 2
    • 3
  • Peter H. Levine
    • 1
    • 2
    • 3
  • Mark H. Johnson
    • 1
    • 2
    • 3
  • Christine H. Vaudreuil
    • 1
    • 2
    • 3
  • Anita Natale
    • 1
    • 2
    • 3
  • James J. Hoogasian
    • 1
    • 2
    • 3
  1. 1.Departments of Medicine and NeurologyWorcester Memorial HospitalUSA
  2. 2.Blood Research LaboratoryWorcester Memorial HospitalUSA
  3. 3.Departments of Medicine and NeurologyUniversity of Massachusetts Medical SchoolUSA

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