Journal of Neurology

, Volume 243, Issue 9, pp 648–651

Mitochondrial DNA levels in the brain of HIV-positive patients after zidovudine therapy

  • F. D. Davison
  • B. J. Sweeney
  • F. Scaravilli
Original Communication

DOI: 10.1007/BF00878661

Cite this article as:
Davison, F.D., Sweeney, B.J. & Scaravilli, F. J Neurol (1996) 243: 648. doi:10.1007/BF00878661

Abstract

Previous studies have shown that the antiviral nucleoside analogue zidovudine (AZT) depletes levels of mitochondrial DNA (mtDNA) in muscle of patients on long-term therapy. In this study we found that in a similar group of eight HIV-positive patients receiving AZT there was no depletion of brain mtDNA. This finding suggests that AZT related mtDNA depletion is not a contributing factor in the HIV encephalopathy that occurs in a proportion of HIV positive patients receiving this antiviral agent.

Key words

Mitochondrial DNAHuman immunodeficiency virusZidovudineDementia

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • F. D. Davison
    • 1
  • B. J. Sweeney
    • 2
  • F. Scaravilli
    • 1
  1. 1.Department of NeuropathologyInstitute of NeurologyLondonUK
  2. 2.Department of Clinical NeurologySt. Mary's HospitalLondonUK