Mitochondrial DNA levels in the brain of HIV-positive patients after zidovudine therapy
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- Davison, F.D., Sweeney, B.J. & Scaravilli, F. J Neurol (1996) 243: 648. doi:10.1007/BF00878661
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Previous studies have shown that the antiviral nucleoside analogue zidovudine (AZT) depletes levels of mitochondrial DNA (mtDNA) in muscle of patients on long-term therapy. In this study we found that in a similar group of eight HIV-positive patients receiving AZT there was no depletion of brain mtDNA. This finding suggests that AZT related mtDNA depletion is not a contributing factor in the HIV encephalopathy that occurs in a proportion of HIV positive patients receiving this antiviral agent.