Pediatric Nephrology

, Volume 6, Issue 3, pp 270–272

Hemolytic uremic syndrome due to Escherichia coli 0157: H7 in a child with multiple infections

  • Daniel B. Ornt
  • Patricia M. Griffin
  • Joy G. Wells
  • Keith R. Powell
Brief Report

DOI: 10.1007/BF00878368

Cite this article as:
Ornt, D.B., Griffin, P.M., Wells, J.G. et al. Pediatr Nephrol (1992) 6: 270. doi:10.1007/BF00878368

Abstract

Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia, thrombocytopenia, and uremia; it is a common cause of acute renal failure in children. Although many microbial agents have been associated with HUS, onlyEscherichia coli 0157∶H7 has been clearly demonstrated to be a major cause of this illness. A case is presented of a healthy 4-year-old boy who had a recent varicella infection; when evaluated for HUS his blood and stool cultures both grewSalmonella montevideo and blood cultures grew group A β-hemolytic streptococci. A stool cultured on MacConkey-sorbitol agar also grewE. coli 0157∶H7. An eightfold rise in serum antibodies toE. coli 0157∶H7 lipopolysachcaride was also demonstrated. The child recovered completely and was healthy 3 years later. Although this child had several infectious agents anecdotally associated with HUS, appropriate culture of stool showed that he also hadE. coli 0157∶H7 infection. Previous cases though to be due to other pathogens may similarly have been caused by co-infection withE. coli 0157∶H7.

Key words

Hemolytic uremic syndrome Escherichia coli 0157∶H7 Multiple infections 

Copyright information

© IPNA 1992

Authors and Affiliations

  • Daniel B. Ornt
    • 1
  • Patricia M. Griffin
    • 2
  • Joy G. Wells
    • 3
  • Keith R. Powell
    • 1
  1. 1.Department of Medicine and PediatricsUniversity of RochesterRochesterUSA
  2. 2.Epidemiology Section, Enteric Diseases Branch, National Center for Infectious DiseasesCenters for Disease ControlAtlantaUSA
  3. 3.Epidemiologic Investigations Laboratory, Enteric Diseases Branch, National Center for Infectious DiseasesCenters for Disease ControlAtlantaUSA

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