Glycine metabolism in anaerobes
- Cite this article as:
- Andreesen, J.R. Antonie van Leeuwenhoek (1994) 66: 223. doi:10.1007/BF00871641
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Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins PB, reduction of sarcosine or betaine to acetyl phosphate involves inEubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein Pc interacting with the intermediarily formed Secarboxymethylselenoether bound to protein PA.