Antonie van Leeuwenhoek

, Volume 66, Issue 1, pp 223–237

Glycine metabolism in anaerobes

  • Jan R. Andreesen
Research Articles

DOI: 10.1007/BF00871641

Cite this article as:
Andreesen, J.R. Antonie van Leeuwenhoek (1994) 66: 223. doi:10.1007/BF00871641


Some strict anaerobic bacteria catalyze with glycine as substrate an internal Stickland reaction by which glycine serves as electron donor being oxidized by glycine-cleavage system or as electron acceptor being reduced by glycine reductase. In both cases, energy is conserved by substrate level phosphorylation. Except for the different substrate-activating proteins PB, reduction of sarcosine or betaine to acetyl phosphate involves inEubacterium acidaminophilum the same set of proteins as observed for glycine, e.g. a unique thioredoxin system as electron donor and an acetyl phosphate-forming protein Pc interacting with the intermediarily formed Secarboxymethylselenoether bound to protein PA.

Key words

Stickland reactionClostridumEubacteriumPeptostreptococcusglycinesarcosinecreatinebetainepurinestheronineprolineglycine cleavage systemglycine reductaseselenoproteinthioredoxin system

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Jan R. Andreesen
    • 1
  1. 1.Institute of MicrobiologyUniversity of HalleHalleGermany