Journal of Behavioral Medicine

, Volume 8, Issue 3, pp 287–299

Riboflavin as a tracer of medication compliance

Authors

  • Patricia M. Dubbert
    • Veterans Administration and University of Mississippi Medical Centers
  • Abby King
    • Veterans Administration and University of Mississippi Medical Centers
  • Stephen R. Rapp
    • Veterans Administration and University of Mississippi Medical Centers
  • Deborah Brief
    • Veterans Administration and University of Mississippi Medical Centers
  • John E. Martin
    • Veterans Administration and University of Mississippi Medical Centers
  • Mary Lake
    • Veterans Administration and University of Mississippi Medical Centers
Article

DOI: 10.1007/BF00870315

Cite this article as:
Dubbert, P.M., King, A., Rapp, S.R. et al. J Behav Med (1985) 8: 287. doi:10.1007/BF00870315

Abstract

Three experiments were conducted to evaluate the accuracy of urine ultraviolet fluorescent tests for riboflavin, which has been used as a tracer for medication compliance in several clinical drug trials. Observer accuracy in discriminating riboflavin-positive or negative urine samples was found to vary with the method of observation, dose of riboflavin, observer experience, and time postingestion. The results showed that, while the 5-mg dose used in previous clinical trials was too small to permit reliable assessment of compliance, larger doses of riboflavin could produce nearly 100% accuracy for minimally trained observers who used a matching-to-sample observation procedure. The findings are discussed in terms of the potential clinical and research applications of this type of simple but reliable compliance assessment procedure.

Key words

medicationcomplianceadherenceriboflavin
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Copyright information

© Plenum Publishing Corporation 1985