Invited Review

Pediatric Nephrology

, Volume 6, Issue 4, pp 383-393

First online:

Aluminum toxicity in childhood

  • Aileen SedmanAffiliated withDepartment of Pediatrics, University of Michigan Medical Center

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Aluminum intoxication is an iatrogenic disease caused by the use of aluminum compounds for phosphate binding and by the contamination of parenteral fluids. Although organ aluminum deposition was noted as early as 1880 and toxicity was documented in the 1960s, the inability to accurately measure serum and tissue aluminum prevented delineation of its toxic effects until the 1970s. Aluminum toxicity has now been conclusively shown to cause encephalopathy, metabolic bone disease, and microcytic anemia.

Key words

Aluminum Childhood renal failure Encephalopathy Osteomalacia Microcytic anemia Aluminum-containing antacids