Journal of Neurology

, Volume 240, Issue 7, pp 446–448

Fatigue, sleep disturbances and circadian rhythm in multiple sclerosis

Authors

  • M. J. B. Taphoorn
    • Department of NeurologyFree University Hospital
  • E. van Someren
    • The Netherlands Institute for Brain Research
  • F. J. Snoek
    • Department of Medical PsychologyFree University Hospital
  • R. L. M. Strijers
    • Department of Clinical NeurophysiologyFree University Hospital
  • D. F. Swaab
    • The Netherlands Institute for Brain Research
  • F. Visscher
    • Department of NeurologyFree University Hospital
  • L. P. de Waal
    • Central Laboratory of the Netherlands Red Cross Blood Transfusion Service
  • C. H. Polman
    • Department of NeurologyFree University Hospital
Original Communications

DOI: 10.1007/BF00867360

Cite this article as:
Taphoorn, M.J.B., van Someren, E., Snoek, F.J. et al. J Neurol (1993) 240: 446. doi:10.1007/BF00867360

Abstract

The aim of this study was to investigate whether fatigue and sleep disturbances in multiple sclerosis (MS) patients might be due to disrupted circadian sleep wake regulation. Actigraphy and a multiple sleep latency test (MSLT) were performed in 16 MS patients with both prominent sleep complaints and fatigue. Actigraphy scores did not differ from control values, whereas sleep onset latency values were altered in subgroups of MS patients. No evidence was found for a generalized circadian disturbance in MS patients.

Key words

Fatigue Sleep Circadian rhythm Multiple sclerosis

Copyright information

© Springer-Verlag 1993