Pediatric Nephrology

, Volume 4, Issue 6, pp 623–626

Exercise tolerance after anaemia correction with recombinant human erythropoietin in end-stage renal disease

Authors

  • Eugenio Baraldi
    • Department of PaediatricsUniversity of Padua
  • Giovanni Montini
    • Department of PaediatricsUniversity of Padua
  • Stefania Zanconato
    • Department of PaediatricsUniversity of Padua
  • Graziella Zacchello
    • Department of PaediatricsUniversity of Padua
  • Franco Zacchello
    • Department of PaediatricsUniversity of Padua
Original Article

DOI: 10.1007/BF00858638

Cite this article as:
Baraldi, E., Montini, G., Zanconato, S. et al. Pediatr Nephrol (1990) 4: 623. doi:10.1007/BF00858638

Abstract

The aim of this study was to evaluate the effect of correction of chronic anaemia on the physical performance and the cardiovascular response to effort in children with end-stage renal disease (ESRD) maintained by haemodialysis. Seven patients (mean age 13.9 years) underwent triangular-type treadmill exercise testing before [haemoglobin (Hb) 6.3±0.9 g/dl] and after (Hb 11.2±1.2 g/dl) anaemia correction with recombinant human erythropoietin (rHuEPO). After treatment, the work-load reached, the peak oxygen uptake and average ventilatory anaerobic threshold (VAT) values were significantly increased (P<0.01,P<0.001,P<0.05 respectively). VAT values, expressed as a percentage of normal values, increased from 55.7±16.6% to 82.4±21%. This improvement correlated well with the increase in Hb (r=0.79). Oxygen pulse also increased significantly, when tested after anacmia correction. In conclusion, these data demonstrate that when the anaemia of children with ESRD is corrected with rHuEPO, there is a clear improvement in acrobic work capacity and effort tolerance.

Key words

HaemodialysisAnaemiaExercise testingRecombinant human erythropoietinRehabilitation

Copyright information

© IPNA 1990