Journal of Behavioral Medicine

, Volume 8, Issue 4, pp 311–320

Distress and DNA repair in human lymphocytes

Authors

  • Janice K. Kiecolt-Glaser
    • Department of PsychiatryThe Ohio State University, College of Medicine
  • Ralph E. Stephens
    • Departments of Radiology, Pathology, and ZoologyThe Ohio State University, College of Medicine
    • The Ohio State University Comprehensive Cancer CenterThe Ohio State University, College of Medicine
  • Philip D. Lipetz
    • General Molecular Applications, Inc.The Ohio State University, College of Medicine
  • Carl E. Speicher
    • Department of PathologyThe Ohio State University, College of Medicine
  • Ronald Glaser
    • The Ohio State University Comprehensive Cancer CenterThe Ohio State University, College of Medicine
    • Department of Medical Microbiology and ImmunologyThe Ohio State University, College of Medicine
Article

DOI: 10.1007/BF00848366

Cite this article as:
Kiecolt-Glaser, J.K., Stephens, R.E., Lipetz, P.D. et al. J Behav Med (1985) 8: 311. doi:10.1007/BF00848366

Abstract

This research assessed differences in DNA repair in lymphocytes from high-and low-distressed individuals. A median split on Minnesota Multiphasic Personality Inventory (MMPI) Scale 2 divided 28 newly admitted nonpsychotic psychiatric inpatients into high- and low-distress subgroups. The high-distress subgroup had significantly poorer DNA repair in lymphocytes exposed to X-irradiation than low-distress subjects. We also found that lymphocytes obtained from this psychiatric sample had significantly poorer DNA repair than lymphocytes from nonpsychiatric control subjects when compared 5 hr after X-irradiation. A high level of distress therefore appears to be associated with significant dysfunctional differences at the molecular level which may have important implications for health. These data provide evidence for a direct pathway through which distress could influence the incidence of cancer.

Key words

distressDNA repairpsychoimmunologystress

Copyright information

© Plenum Publishing Corporation 1985