Stress and the transformation of lymphocytes by Epstein-Barr virus
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
Although various stressors appear to influence herpesvirus infections, the underlying mechanisms have not been studied. A prospective design was used to examine the effects of examination stress and loneliness on the transformation of B lymphocytes in mixed cultures of T and B lymphocytes by Epstein-Barr virus (EBV). Three blood samples were drawn from 42 EBV-seropositive medical students, with the baseline sample taken 1 month before their final examinations, the stress sample drawn on the first day of final examinations, and the third sample taken the first week after their return from summer vacation. A median split on the UCLA Loneliness Scale divided the subjects into high- and low-scoring loneliness groups. There were significant effects for change over trials, with the lowest transformation levels (i.e., more virus required to transform cells) found in the stress sample. There was also a significant main effect for loneliness, in which high loneliness was associated with lower transformation levels. Possible immunological pathways for the observed changes are discussed.
- Derogatis, L. R. (1977).SCL-90 R-(Revised) Version Manual-I, Clinical Psychometrics Research, Baltimore.
- Glaser, R., and Gottleib-Stematsky, T. (eds.) (1982).Human Herpesvirus Infections: Clinical Aspects, Marcel Dekker, New York.
- Glaser, R., Kiecolt-Glaser, J. K., Holliday, J., and Speicher, C. (1984). The relationship of stress and loneliness to Herpesvirus antibody titers (submitted for publication).
- Glaser, R., Nonoyama, M., Decker, B., and Rapp, F. (1973). Synthesis of Epstein-Barr virus antigens and DNA in activated Burkitt somatic cell hybrids.Virology 55: 62–69.
- Goldmeier, D., and Johsnon, A. (1982). Does psychiatric illness affect the recurrence rate of genital herpes.Br. J. Vener. Dis. 58: 40–43.
- Gottleib-Stematsky, T., and Glaser, R. (1982). Association of Epstein-Barr virus with neurologic diseases. In Glaser, R., and Gottleib-Stematsky, T. (eds.),Human Herpes-virus Infections: Clinical Aspects, Marcel Dekker, New York.
- Hanto, D. W., Friaaera, G., Purtilo, D. T., Sakamoto, K., Sullivan, J. L., Saemundsen, A. K., Klein, G., Simmons, R. L., and Najarian, J. S. (1981). Clinical spectrum of lymphoproliferative disorders in renal transplant recipients and evidence for the role of Epstein-Barr virus.Cancer Res. 41: 4253–4261.
- Henle, W., and Henle, G. (1981). Epstein-Barr virus-specific serology in immunological compromised individuals.Cancer Res. 41: 4222–4225.
- Henle, W., and Henle, G. (1982). Epstein-Barr virus and infectious mononucleosis. In Glaser, R., and Gottleib-Stematsky, T. (eds.),Human Herpesvirus Infections: Clinical Aspects, Marcel Dekker, New York.
- Henry, B. E., Glaser, R., Hewetson, J., and O'Callaghan, D. J. (1978). Expression of altered ribonucleotide reductase activity associated with the replication of the Epstein-Barr virus.Virology 89: 262–271.
- Kasl, S. V., Evans, A. S., and Niederman, J. C. (1979). Psychosocial risk factors in the development of infectious mononucleosis.Psychosom. Med. 41: 445–466.
- Kiecolt-Glaser, J. K., Garner, W., Speicher, C., Penn, G. M., Holliday, J., and Glaser, R. (1984a). Psychosocial modifiers of immunocompetence in medical students.Psychosom. Med. 46: 7–14.
- Kiecolt-Glaser, J. K., Ricker, D., Messick, G., Speicher, C., Holliday, J., Garner, W., and Glaser, R. (1984b). Urinary cortisol levels, cellular immunocompetency, and loneliness in psychiatric inpatients.Psychosom. Med. 46: 15–24.
- Luborsky, L., Mintz, J., Brightman, V. J., and Katcher, A. H. (1976). Herpes simplex and moods: A longitudinal study.J. Psychosom. Res. 20: 543–548.
- Monjan, A. A. (1981). Stress and immunologic competence: Studies in animals. In Ader, R. (ed.),Psychoneuroimmunology, Academic Press, New York.
- Peplau, L. A., and Perlman, D. (eds.) (1982).Loneliness: A Sourcebook of Current Theory, Research and Therapy, John Wiley and Sons, New York.
- Pope, J. H. (1979). Transformation by the virusin vitro. In Epstein, M. A., and Achong, B. G. (eds.),The Epstein-Barr Virus, Springer-Verlag, New York.
- Purtilo, D. T., Sakamoto, K., Saemundsen, A. K., Sullivan, J. L., Synnerholm, A. C., Anvret, M., Pritchard, J., Sloper, C., Sieff, C., Pincott, J., Pachman, L., Fich, K., Cruzi, F., Cornet, J. A., Collins, R., Barnes, N., Knight, J., Sandstedt, B., and Klein, G. (1981). Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by clinical, virological and immunopathological studies.Cancer Res. 41: 4226–4236.
- Rickinson, A. B., Moss, D. J., Wallace, L. E., Rowe, M., Misko, I. S., Epstein, M. A., and Pope, J. H. (1981). Long-term T-cell-mediated immunity to Epstein-Barr virus.Cancer Res. 41: 4216–4221.
- Russell, D., Peplau, L. A., and Cutrona, C. E. (1980). The revised UCLA Loneliness Scale: Concurrent and discriminant validity evidence.J. Pers. Soc. Psychol. 39: 472–480.
- Saemundsen, A. K., Purtillo, D. T., Sakaniti, K., Sullivan, J. L., Synnerholm, A. C., Hanto, D., Simmons, R., Anvret, M., Collins, R., and Klein, G. (1981). Documentation of Epstein-Barr virus infection in immunodeficient patients with life-threatening lymphoproliferative diseases by Epstein-Barr virus complementary RNA/DNA and viral RNA/DNA hybridization.Cancer Res. 41: 4237–4242.
- Shaver, P., Furman, W., Buhrmester, D., and Williams, T. (1981). State and trait loneliness during the transition into college. Paper presented at the annual meeting of the American Psychological Association, Los Angeles, Calif., August 1981.
- Thoits, P. A. (1982). Conceptual, methodological and theoretical problems in studying social supports as a buffer against life stress.J. Health Soc. Behav. 23: 145–159.
- Tuckwiller, L. S., and Glaser, R. (1983). Epstein-Barr virus and nasopharyngeal carcinoma. In Reznick-Schuller (ed.),Comparative Respiratory Tract Carcinogenesis, CRC Press, Cleveland, Ohio.
- Stress and the transformation of lymphocytes by Epstein-Barr virus
Journal of Behavioral Medicine
Volume 7, Issue 1 , pp 1-12
- Cover Date
- Print ISSN
- Online ISSN
- Kluwer Academic Publishers-Plenum Publishers
- Additional Links
- Epstein-Barr virus
- immune response
- Author Affiliations
- 1. Department of Psychiatry, The Ohio State University College of Medicine, 43210, Columbus, Ohio
- 3. Department of Pathology, The Ohio State University College of Medicine, 43210, Columbus, Ohio
- 4. Department of Medical Microbiology and Immunology, The Ohio State University College of Medicine, 43210, Columbus, Ohio
- 5. Comprehensive Cancer Center, The Ohio State University College of Medicine, 43210, Columbus, Ohio