Journal of Neurology

, Volume 240, Issue 5, pp 295–298

A double blind study on azathioprine efficacy in multiple sclerosis: final report

  • C. Milanese
  • L. La Mantia
  • A. Salmaggi
  • M. Eoli
Original Communications

DOI: 10.1007/BF00838165

Cite this article as:
Milanese, C., La Mantia, L., Salmaggi, A. et al. J Neurol (1993) 240: 295. doi:10.1007/BF00838165

Abstract

Forty patients, affected by multiple sclerosis with remitting-relapsing or progressive course, were included in a double blind study of treatment with azathioprine (2 mg/kg/day) lasting 3 years. The mean changes on the Expanded Disability Status Scale and in the survival analysis show a trend in favour of azathioprine both in slowing disease progression and reducing relapse frequency. These findings, repeatedly observed in similar trials, indicate that azathioprine should be used in the treatment of multiple sclerosis.

Key words

Multiple sclerosisAzathioprine

Copyright information

© Springer-Verlag 1993

Authors and Affiliations

  • C. Milanese
    • 1
  • L. La Mantia
    • 1
  • A. Salmaggi
    • 1
  • M. Eoli
    • 1
  1. 1.Istituto Nazionale Neurologico C. BestaMilanItaly