Pharmacy World and Science

, Volume 18, Issue 5, pp 182–186

Investigation on the chemical stability of erythromycin in solutions using an optimization system

  • M. Brisaert
  • M. Heylen
  • J. Plaizier-Vercammen
Articles

DOI: 10.1007/BF00820730

Cite this article as:
Brisaert, M., Heylen, M. & Plaizier-Vercammen, J. Pharm World Sci (1996) 18: 182. doi:10.1007/BF00820730

Abstract

Erythromycin, an antibiotic commonly used topically in the treatment of acne, is unstable in solution. The stability is influenced by the pH and by the presence of water. The influence of the pH on the stability of erythromycin was investigated even with the use of dimethyl isosorbide as co-solvent instead of water. The addition of zinc was attempted to ameliorate erythromycin stability as suggested in the literature. To investigate these three factors and their interactions, an optimization technique was carried out consisting of a 23 factorial analysis and a rotative central composite design. The erythromycin solutions were analysed with an HPLC method. The pH and the concentration of dimethyl isosorbide had a significant influence on the stability of erythromycin but the addition of zinc was not a significant factor. Moreover, there was a significant interaction between the pH and dimethyl isosorbide.

Keywords

Erythromycin Chemical stability Topical solutions HPLC analysis Composite design with 3 factors: pH, conc DMI and conc Zn 

Copyright information

© Kluwer Academic Publishers 1996

Authors and Affiliations

  • M. Brisaert
    • 1
  • M. Heylen
    • 1
  • J. Plaizier-Vercammen
    • 1
  1. 1.Vrije Universiteit BrusselPharmaceutical Institute, Pharmaceutical Technology and Physical PharmacyBrusselsBelgium

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