Journal of Bioenergetics and Biomembranes

, Volume 21, Issue 5, pp 621-632

First online:

Molecular properties of the fungal plasma-membrane [H+]-ATPase

  • Robert K. NakamotoAffiliated withDepartment of Human Genetics, Yale School of Medicine
  • , Carolyn W. SlaymanAffiliated withDepartment of Human Genetics, Yale School of MedicineDepartment of Cellular and Molecular Physiology, Yale School of Medicine

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The fungal plasma membrane contains a proton-translocating ATPase that is closely related, both structurally and functionally, to the [Na+, K+]-, [H+, K+]-, and [Ca2+]-ATPases of animal cells, the plasma-membrane [H+]-ATPase of higher plants, and several bacterial cation-transporting ATPases. This review summarizes currently available information on the molecular genetics, protein structure, and reaction cycle of the fungal enzyme. Recent efforts to dissect structure-function relationships are also discussed.

Key Words

ATPase [H+]-ATPase proton transport Neurospora crassa Saccharomyces cerevisiae Schizosaccharomyces pombe