Site specificity of protein glycation
- Cite this article as:
- Walton, D.J. & Shilton, B.H. Amino Acids (1991) 1: 199. doi:10.1007/BF00806917
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The rate of nonenzymatic glycation of a protein amino group is dependent upon a number of factors, such as the accessibility to glucose molecules in solution, and local acid-base catalysis of the rearrangement of the Schiff base that is formed initially. This is illustrated by a study of the site specificity of liver alcohol dehydrogenase, in which an attempt has been made to interpret the data in terms of the three-dimensional structure of the enzyme molecule.