Amino Acids

, Volume 1, Issue 2, pp 199–203

Site specificity of protein glycation


  • D. J. Walton
    • Department of BiochemistryQueen's University
  • B. H. Shilton
    • Department of BiochemistryQueen's University

DOI: 10.1007/BF00806917

Cite this article as:
Walton, D.J. & Shilton, B.H. Amino Acids (1991) 1: 199. doi:10.1007/BF00806917


The rate of nonenzymatic glycation of a protein amino group is dependent upon a number of factors, such as the accessibility to glucose molecules in solution, and local acid-base catalysis of the rearrangement of the Schiff base that is formed initially. This is illustrated by a study of the site specificity of liver alcohol dehydrogenase, in which an attempt has been made to interpret the data in terms of the three-dimensional structure of the enzyme molecule.


Amino acidsProteinEnzymeGlycationGlycosylation
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© Springer-Verlag 1991