Basic Research in Cardiology

, Volume 91, Supplement 1, pp 85–90

Activated tissue renin-angiotensin systems add to the progression of heart failure

Authors

  • Y. M. Pinto
    • Dept. of Cardiology and Dept. of Clinical PharmacologyUniversity of Groningen
  • H. Buikema
    • Dept. of Cardiology and Dept. of Clinical PharmacologyUniversity of Groningen
  • Wiek H. van Gilst
    • Dept. of Cardiology and Dept. of Clinical PharmacologyUniversity of Groningen
  • K. I. Lie
    • Dept. of Cardiology and Dept. of Clinical PharmacologyUniversity of Groningen
Article

DOI: 10.1007/BF00795368

Cite this article as:
Pinto, Y.M., Buikema, H., van Gilst, W.H. et al. Basic Res Cardiol (1996) 91: 85. doi:10.1007/BF00795368

Abstract

In this paper, we review the hypothesis that activated tissue renin-angiotensin systems play a detrimental role in heart failure. The main arguments for this idea are discussed:
  1. a)

    tissue renin-angiotensin systems behave functionally distinct from the circulating renin-angiotensin system;

     
  2. b)

    tissue renin-angiotensin systems are activated in heart failure;

     
  3. c)

    activated tissue renin-angiotensin systems induce cardiovascular dysfunction.

     

Finally, this hypothesis predicts that optimal treatment in heart failure requires the inhibition of tissue renin-angiotensin systems. However, studies pertaining to this prediction are still lacking, particularly in human subjects.

Key words

Review-tissue renin-angiotensin systemsheart failureexperimental-clinical

Copyright information

© Steinkopff Verlag 1996