Virchows Archiv A

, Volume 413, Issue 4, pp 297–302

Estrogen receptors in gastric adenocarcinoma: A retrospective immunohistochemical analysis

Authors

  • Hiroshi Yokozaki
    • Department of PathologyHiroshima University School of Medicine
  • Naoki Takekura
    • Department of PathologyHiroshima University School of Medicine
  • Atsushi Takanashi
    • Department of PathologyHiroshima University School of Medicine
  • Junji Tabuchi
    • Department of PathologyHiroshima University School of Medicine
  • Rumi Haruta
    • Department of PathologyHiroshima University School of Medicine
  • Eiichi Tahara
    • Department of PathologyHiroshima University School of Medicine
Article

DOI: 10.1007/BF00783021

Cite this article as:
Yokozaki, H., Takekura, N., Takanashi, A. et al. Vichows Archiv A Pathol Anat (1988) 413: 297. doi:10.1007/BF00783021

Summary

Estrogen receptors (ER) in human gastric carcinomas were examined immunohistochemically using a specific monoclonal antibody to human ER. ER-immunoreactivity (ER-IR) was positive in 30 (27.8%) of the 108 gastric carcinomas examined. ER-IR was located in the nucleus of cancer cells. The incidence of ER-IR positive gastric carcinoma was not significantly different between male and female cases. However, the positive tumour cells were observed in 28 (39.4%) out of the 71 poorly differentiated adenocarcinoma, the incidence being significantly higher than that in well differentiated adenocarcinoma (p<0.01). There was no significant difference in the incidence of ER-IR between scirrhous carcinoma and non-scirrhous poorly differentiated adenocarcinoma. Synchronous expression of ER and epidermal growth factor receptor was found in 8 of the 26 scirrhous carcinomas (30.8%). Patients with ER-IR positive scirrhous gastric carcinomas showed a much worse prognosis than those with ER-IR negative scirrhous carcinomas.

Key words

Estrogen receptorGastric carcinomaImmunohistochemistry

Copyright information

© Springer-Verlag 1988