Originals

Acta Diabetologica

, Volume 28, Issue 3, pp 229-232

HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease

  • E. BognettiAffiliated withDepartment of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan
  • , F. MeschiAffiliated withDepartment of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan
  • , C. MalavasiAffiliated withDepartment of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan
  • , M. R. PastoreAffiliated withDepartment of Internal Medicine, San Raffaele Scientific Institute, University of Milan
  • , A. SergiAffiliated withDepartment of Internal Medicine, San Raffaele Scientific Institute, University of Milan
  • , M. T. IlleniAffiliated withDepartment of Immunohaematology, Istituto Nazionale dei Tumori
  • , C. MaffeisAffiliated withDepartment of Paediatrics, University of Verona
  • , L. PinelliAffiliated withDepartment of Paediatrics, University of Verona
  • , G. ChiumelloAffiliated withDepartment of Paediatrics, Endocrine Unit, San Raffaele Scientific Institute, University of Milan

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Abstract

HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease.

Key words

HLA Insulin-dependent diabetes mellitus Breast feeding Childhood