Acta Diabetologica

, Volume 28, Issue 3, pp 229–232

HLA antigens in Italian type 1 diabetic patients: role of DR3/DR4 antigens and breast feeding in the onset of the disease

  • E. Bognetti
  • F. Meschi
  • C. Malavasi
  • M. R. Pastore
  • A. Sergi
  • M. T. Illeni
  • C. Maffeis
  • L. Pinelli
  • G. Chiumello
Originals

DOI: 10.1007/BF00779004

Cite this article as:
Bognetti, E., Meschi, F., Malavasi, C. et al. Acta Diabetol (1992) 28: 229. doi:10.1007/BF00779004

Abstract

HLA-A, B, C, DR and DQ typing was performed in 381 Italian insulin-dependent diabetic patients and in 905 normal Italian subjects. The diabetic patients had significantly higher frequencies of HLA-Cw7, B8, B18, DR3, DR4, DQw2 and DQw3 and significantly lower frequencies of HLA-B17, Bw51, DR2, DR7 and DRw11. The frequency of heterozygosity for HLA-DR3/DR4 was significantly higher in patients who developed the disease in the first 2 years of life and DR3+/DR4-, DQw2 and DQw3 alleles were higher in those aged less than 14 years at onset. The HLA-DR4 allele was associated with onset of diabetes in autumn and HLA-B18 with onset in Autumn-winter. Diabetic children who were breast fed had a later onset of insulin-dependent diabetes mellitus than those who were bottle fed but these differences were independent of HLA typing (11.18±0.72 years vs 9.23±0.42 years; mean±SEM). We conclude that: (1) in general, HLA distribution in Italian insulin-dependent diabetic patients reflects previous data reported in other European and North American populations; (2) HLA-DR3 and DR4 are strongly associated with insulin-dependent diabetes in Italy as well, and these alleles seem to predispose to an earlier onset of the disease; and (3) breast feeding may delay the onset of the disease.

Key words

HLAInsulin-dependent diabetes mellitusBreast feedingChildhood

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • E. Bognetti
    • 1
  • F. Meschi
    • 1
  • C. Malavasi
    • 1
  • M. R. Pastore
    • 2
  • A. Sergi
    • 2
  • M. T. Illeni
    • 3
  • C. Maffeis
    • 4
  • L. Pinelli
    • 4
  • G. Chiumello
    • 1
  1. 1.Department of Paediatrics, Endocrine Unit, San Raffaele Scientific InstituteUniversity of MilanMilanItaly
  2. 2.Department of Internal Medicine, San Raffaele Scientific InstituteUniversity of MilanMilanItaly
  3. 3.Department of ImmunohaematologyIstituto Nazionale dei TumoriMilanItaly
  4. 4.Department of PaediatricsUniversity of VeronaVeronaItaly
  5. 5.Department of PaediatricsSan Raffaele Scientific InstituteMilanItaly