5α-Reductase inhibitory component from leaves ofArtocarpus altilis
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- Shimizu, K., Kondo, R., Sakai, K. et al. J Wood Sci (2000) 46: 385. doi:10.1007/BF00776401
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The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves ofArtocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves ofA. altilis. This compound showed more potent inhibitory effect (IC50=38ΜM) thanα-linolenic acid known as a naturally occurring potent inhibitor.