Journal of Wood Science

, 46:385

5α-Reductase inhibitory component from leaves ofArtocarpus altilis

  • Kuniyoshi Shimizu
  • Ryuichiro Kondo
  • Kokki Sakai
  • Supanida Buabarn
  • Uraiwan Dilokkunanant
Original Article

DOI: 10.1007/BF00776401

Cite this article as:
Shimizu, K., Kondo, R., Sakai, K. et al. J Wood Sci (2000) 46: 385. doi:10.1007/BF00776401

Abstract

The inhibitory effects of 17 samples prepared from Thailand plants on 5α-reductase activity were examined. The acetone extract of leaves ofArtocarpus altilis showed potent 5α-reductase inhibitory activity. Fractionation guided by 5α-reductase inhibition led to the isolation of 2-geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone from the acetone extract of leaves ofA. altilis. This compound showed more potent inhibitory effect (IC50=38ΜM) thanα-linolenic acid known as a naturally occurring potent inhibitor.

Key words

Artocarpus altilis (Parkins) FosbergMoraceaeLeaves5α-Reductase inhibitor2-Geranyl-2′,3,4,4′-tetrahydroxydihydrochalcone

Copyright information

© The Japan Wood Research Society 2000

Authors and Affiliations

  • Kuniyoshi Shimizu
    • 1
  • Ryuichiro Kondo
    • 1
  • Kokki Sakai
    • 1
  • Supanida Buabarn
    • 2
  • Uraiwan Dilokkunanant
    • 2
  1. 1.Department of Forest Products, Faculty of AgricultureKyushu UniversityFukuokaJapan
  2. 2.Kasetsart Agriculture and Agro-Industrial Product Improvement InstituteKasetsart UniversityBangkokThailand