, Volume 100, Issue 1, pp 27–35

Action of chlorhexidine on buddingCandida albicans: Scanning and transmission electron microscopic study

  • Hélène Bobichon
  • Philippe Bouchet

DOI: 10.1007/BF00769565

Cite this article as:
Bobichon, H. & Bouchet, P. Mycopathologia (1987) 100: 27. doi:10.1007/BF00769565


Chlorhexidine is widely used as a bacterial drug whose method of action has been well described in bacteria. Its fungicidal properties have been proved. We show here the effects of a sublethal dose of a preparation of digluconate of chlorhexidine on buddingCandida albicans. A fungistatic action is revealed by a decrease in the percentage of budding cells, and two main types of alterations can be observed with transmission electron microscopy (T.E.M.): a loss of cytoplasmic components and a coagulation of nucleoproteins. With scanning electron microscopy (S.E.M.), the cell walls show morphological modifications.

Key words

chlorhexidine Candida ultrastructure 

Copyright information

© Martinus Nijhoff/Dr W. Junk Publishers 1987

Authors and Affiliations

  • Hélène Bobichon
    • 1
  • Philippe Bouchet
    • 1
  1. 1.Faculté de PharmacieLaboratoire de Biologie Végétale et CryptogamieReims, CédexFrance

Personalised recommendations