Action of chlorhexidine on buddingCandida albicans: Scanning and transmission electron microscopic study
- Cite this article as:
- Bobichon, H. & Bouchet, P. Mycopathologia (1987) 100: 27. doi:10.1007/BF00769565
Chlorhexidine is widely used as a bacterial drug whose method of action has been well described in bacteria. Its fungicidal properties have been proved. We show here the effects of a sublethal dose of a preparation of digluconate of chlorhexidine on buddingCandida albicans. A fungistatic action is revealed by a decrease in the percentage of budding cells, and two main types of alterations can be observed with transmission electron microscopy (T.E.M.): a loss of cytoplasmic components and a coagulation of nucleoproteins. With scanning electron microscopy (S.E.M.), the cell walls show morphological modifications.