Journal of Bioenergetics and Biomembranes

, Volume 24, Issue 1, pp 71–75

Evidence for extra-mitochondrial localization of the VDAC/porin channel in eucaryotic cells

  • Friedrich P. Thinnes

DOI: 10.1007/BF00769533

Cite this article as:
Thinnes, F.P. J Bioenerg Biomembr (1992) 24: 71. doi:10.1007/BF00769533


The expression of bacterial porin in outer membranes of gram-negative bacteria and of mitochondrial porin or voltage-dependent anion channel (VDAC) in outer mitochondrial membranes (OMM) of eucaryotic cells was demonstrated about 15 years ago. However, the expression of VDAC in the plasmalemma (PLM) of transformed human B lymphoblasts has recently been indicated by cytotoxicity and indirect immunofluorescence studies. New data suggest that the expression of VDAC may be even more widespread. Different cell types express porin channels in their PLM and in intracellular membranes other than OMM. The functional expression of these channels may differ in the various compartments since recent experiments have demonstrated that the voltage dependence and ion selectivity of mitochondrial VDAC may be altered by their interaction with modulators. The present paper proposes a unifying concept for the ion-selective channels of cell membranes, in particular, those whose regulation is affected in cystic fibrosis.

Key words

Porin VDAC plasma membrane cystic fibrosis chloride channel sodium channel long-term potentiation long-term depression endosymbiotic theory 

Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • Friedrich P. Thinnes
    • 1
  1. 1.Abteilung ImmunchemieMax-Planck-Institut für Experimentelle MedizinGöttingenGermany