Journal of Bioenergetics and Biomembranes

, Volume 22, Issue 2, pp 157–179

Molecular mechanisms of calcium-induced membrane fusion


  • Demetrios Papahadjopoulos
    • Cancer Research InstituteUniversity of California
    • Department of PharmacologyUniversity of California
  • Shlomo Nir
    • The Seagram Center, Faculty of AgricultureHebrew University of Jerusalem
  • Nejat Düzgünes
    • Cancer Research InstituteUniversity of California
    • Department of Pharmaceutical ChemistryUniversity of California

DOI: 10.1007/BF00762944

Cite this article as:
Papahadjopoulos, D., Nir, S. & Düzgünes, N. J Bioenerg Biomembr (1990) 22: 157. doi:10.1007/BF00762944


We have reviewed studies on calcium-induced fusion of lipid bilayer membranes and the role of synexin and other calcium-binding proteins (annexins) in membrane fusion. We have also discussed the roles of other cations, lipid phase transitions, long chain fatty acids and other fusogenic molecules. Finally, we have presented a simple molecular model for the mechanism of lipid membrane fusion, consistent with the experimental evidence and incorporating various elements proposed previously.

Key Words

Liposomes annexins membrane-fusion model-membranes calcium lipid-bilayer calcium-binding-proteins

Copyright information

© Plenum Publishing Corporation 1990