Journal of Bioenergetics and Biomembranes

, Volume 26, Issue 4, pp 359–367

Transport of vitamin C in animal and human cells

  • Hans Goldenberg
  • Esther Schweinzer

DOI: 10.1007/BF00762776

Cite this article as:
Goldenberg, H. & Schweinzer, E. J Bioenerg Biomembr (1994) 26: 359. doi:10.1007/BF00762776


The transport systems of animal and human tissues for vitamin C are reviewed with respect to their properties. It emerges that pure diffusion plays only a very minor role, while a variety of more or less specific transporters is found on cellular membranes. Although most tissues prefer the reduced ascorbate over the oxidized dehydroascorbic acid and have high-affinity transporters for it, there are several examples for the reversed situation. Special attention is given to similarity or identity with glucose transporters, especially the GLUT-1 and the sodium-dependent intestinal and renal transporters, and to the very widespread dependence of ascorbate transport on sodium ions. The significance of ascorbate transport for vitamin C-requiring and nonrequiring species as well as alterations in states of disease can be seen from ample experimental evidence.

Key words

Ascorbate transport oxidized dehydroascorbic acid high affinity transporters 

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Hans Goldenberg
    • 1
  • Esther Schweinzer
    • 1
  1. 1.Department of Medical ChemistryUniversity of ViennaViennaAustria

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