Journal of Bioenergetics and Biomembranes

, Volume 26, Issue 4, pp 359–367

Transport of vitamin C in animal and human cells

  • Hans Goldenberg
  • Esther Schweinzer

DOI: 10.1007/BF00762776

Cite this article as:
Goldenberg, H. & Schweinzer, E. J Bioenerg Biomembr (1994) 26: 359. doi:10.1007/BF00762776


The transport systems of animal and human tissues for vitamin C are reviewed with respect to their properties. It emerges that pure diffusion plays only a very minor role, while a variety of more or less specific transporters is found on cellular membranes. Although most tissues prefer the reduced ascorbate over the oxidized dehydroascorbic acid and have high-affinity transporters for it, there are several examples for the reversed situation. Special attention is given to similarity or identity with glucose transporters, especially the GLUT-1 and the sodium-dependent intestinal and renal transporters, and to the very widespread dependence of ascorbate transport on sodium ions. The significance of ascorbate transport for vitamin C-requiring and nonrequiring species as well as alterations in states of disease can be seen from ample experimental evidence.

Key words

Ascorbate transportoxidized dehydroascorbic acidhigh affinity transporters

Copyright information

© Plenum Publishing Corporation 1994

Authors and Affiliations

  • Hans Goldenberg
    • 1
  • Esther Schweinzer
    • 1
  1. 1.Department of Medical ChemistryUniversity of ViennaViennaAustria