Journal of Bioenergetics and Biomembranes

, Volume 19, Issue 3, pp 297–303

Action of cyclosporine on mitochondrial calcium fluxes

Authors

  • N. Fournier
    • Laboratoire de BiophysiqueFaculté de Pharmacie
  • G. Ducet
    • Laboratoire de Physiologie CellulaireFaculte des Sciences
  • A. Crevat
    • Laboratoire de BiophysiqueFaculté de Pharmacie
Research Articles

DOI: 10.1007/BF00762419

Cite this article as:
Fournier, N., Ducet, G. & Crevat, A. J Bioenerg Biomembr (1987) 19: 297. doi:10.1007/BF00762419

Abstract

Cyclosporine (Cys A) is a potent immunosuppressor used to reduce rejection in transplantation surgery. We studied its action upon mitochondrial functions: oxidative phosphorylation and Ca2+ movements through mitochondrial membrane. We show that Cys A exhibits an inhibitory effect upon mitochondrial respiration. This result is in good agreement with previous works and may be correlated with Cys A toxicity. The action of cyclosporine on calcium fluxes is more pronounced. Indeed it blocks mitochondrial calcium efflux and allows mitochondria to accumulate a large amount of calcium. If this effect occurs in the cell, it would induce a Ca2+ decrease in cytosol. This action might be correlated with the inhibitory effect of Cys A upon the mitogenic stimulation of T lymphocytes.

Key Words

Cyclosporinecalciummitochondria

Copyright information

© Plenum Publishing Corporation 1987