Virchows Archiv A

, Volume 412, Issue 3, pp 273–279

Osteosarcoma with a clear-cell component

  • Ctibor Povýšil
  • Zdeněk Matějovský
  • Helena Zídková

DOI: 10.1007/BF00737152

Cite this article as:
Povýšil, C., Matějovský, Z. & Zídková, H. Vichows Archiv A Pathol Anat (1988) 412: 273. doi:10.1007/BF00737152


The reports concerns the light microscopical and ultrastructural findings obtained in three conventional osteosarcomas with an unusually high admixture of clear cells, whose presence appeared to be responsible for the marked change in the histological pattern of these tumours. In the tumours with a prevailing fibroblastic component the clear cells were either irregularly scattered throughout the tumour in the form of small groups, or they formed large groups sharply demarcated against the fusicellular areas of the tumours. In two cases it was shown that their cytoplasm contained exaggerated glycogen deposits accompanied by the formation of glycogen-containing phagolysosomes and occasional empty vacuoles. In the third case the clear cells showed vacuolar degeneration with numerous single-membrane-bound, empty vacuoles. In contrast to the clear-cell chondrosarcoma we did not find S-100 protein in clear cells of our osteosarcomas. Such findings could be particularly significant in the differential diagnosis of bone tumours.

Key words

OsteosarcomaClear cellHistopathologyElectron microscopy

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Ctibor Povýšil
    • 1
  • Zdeněk Matějovský
    • 2
  • Helena Zídková
    • 3
  1. 1.2nd Institute of Pathology, Faculty of General MedicineCharles UniversityPraha 2Czechoslovakia
  2. 2.Orthopedic ClinicInstitute for Postgraduate StudiesPragueCzechoslovakia
  3. 3.Radiodiagnostic ClinicInstitute for Postgraduate StudiesPragueCzechoslovakia