Glycoconjugate Journal

, Volume 11, Issue 5, pp 414–417

PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence ofPseudomonas aeruginosa to human tissues in secondary infections

Authors

  • Nechama Gilboa-Garber
    • Department of Life SciencesBar-Ilan University
  • Dvora Sudakevitz
    • Department of Life SciencesBar-Ilan University
  • Masha Sheffi
    • Department of Life SciencesBar-Ilan University
  • Ruth Sela
    • The Blood Group Reference LaboratoryMinistry of Health
  • Cyril Levene
    • The Blood Group Reference LaboratoryMinistry of Health
Lectin Papers

DOI: 10.1007/BF00731276

Cite this article as:
Gilboa-Garber, N., Sudakevitz, D., Sheffi, M. et al. Glycoconjugate J (1994) 11: 414. doi:10.1007/BF00731276

Abstract

Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to thed-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to thel-fucose of H, A and B antigens. IntactP. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.

Keywords

Pseudomonas aeruginosa adherencelectin interactionsglycosphingolipid antigensABO blood groupP system antigens
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Copyright information

© Chapman & Hall 1994