Short Communications

European Journal of Pediatrics

, Volume 146, Issue 3, pp 292-293

First online:

Osteomalacia of the mother —rickets of the newborn

  • W. ParkAffiliated withDepartment of Pediatrics, Free University Berlin
  • , H. PaustAffiliated withDepartment of Pediatrics, Free University Berlin
  • , H. J. KaufmannAffiliated withDepartment of Pediatric Radiology, Free University Berlin
  • , G. OffermannAffiliated withDepartment of Internal Medicine, Free University Berlin

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Abstract

During the last 4 years we observed four cases of neonatal rickets. The mothers of the infants suffered from osteomalacia for 1–3 years prior to its diagnosis shortly after the birth of their children. All four infants were born with craniotabes, and one infant had, in addition, a radial fracture. The diagnoses were confirmed by radiological and laboratory tests which revealed a rarefied bone structure, decreased serum 25-hydroxy-vitamin D and increased alkaline phosphatase levels in all patients. The disorder regressed under low-dose vitamin D3 therapy. As osteomalacia seems to be predominant in oriental women living in Berlin, it is necessary to consider vitamin D deficiency when clinical symptoms of this disease arise and to treat these women at least during pregnancy.

Key words

Osteomalacia Neonatal rickets 25-hydroxy-vitamin D