Originals

European Journal of Clinical Pharmacology

, Volume 14, Issue 6, pp 417-423

First online:

Effects of terfenadine and diphenhydramine alone or in combination with diazepam or alcohol on psychomotor performance and subjective feelings

  • Liselotte MoserAffiliated withGesellschaft für Ursachenforschung bei Verkehrsunfällen
  • , K. J. HütherAffiliated withCentre de Recherche Merrell International
  • , J. Koch-WeserAffiliated withCentre de Recherche Merrell International
  • , P. V. LundtAffiliated withGesellschaft für Ursachenforschung bei Verkehrsunfällen

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Summary

The effects of single oral doses of terfenadine, diphenhydramine and placebo, alone or in combination with diazepam or alcohol, on psychomotor performance and subjective feelings were evaluated in a double-blind, crossover study in 20 normal male volunteers. Terfenadine 60, 120 and 240 mg had no effect on psychomotor skills and subjective feelings, whereas diphenhydramine 100 mg slightly impaired certain features of psychomotor performance and severely worsened subjective feelings. Terfenadine 120 mg did not influence the adverse effects of oral diazepam 10 mg or of alcohol 0.75 g/kg on psychomotor performance and subjective feelings. In contrast, diphenhydramine 100 mg significantly enhanced these effects of diazepam and alcohol.

Key words

Histamine antagonists terfenadine diphenhydramine diazepam alcohol drug interactions effects on psychomotor performance and subjective feelings