Chromosome Research

, Volume 3, Issue 4, pp 261–262

Mapping of gene loci in the Q13–Q15 region of chromosome 12

  • Erika L. D. Mitchell
  • Gavin R. M. White
  • Mauro F. Santibanez-Koref
  • Jenny M. Varley
  • Jim Heighway
Short Communication

DOI: 10.1007/BF00713052

Cite this article as:
Mitchell, E.L.D., White, G.R.M., Santibanez-Koref, M.F. et al. Chromosome Res (1995) 3: 261. doi:10.1007/BF00713052

Abstract

The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13–q15 region of chromosome 12. Using fluorescencein situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3–14.1, CDK4 to 12q14 and MDM2 to 12q14.3–q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.

Key words

chromosome 12 gene mapping 12q13–q15 

Copyright information

© Rapid Communications of Oxford Ltd 1995

Authors and Affiliations

  • Erika L. D. Mitchell
    • 1
  • Gavin R. M. White
    • 1
  • Mauro F. Santibanez-Koref
    • 1
  • Jenny M. Varley
    • 1
  • Jim Heighway
    • 1
  1. 1.the Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer ResearchChristie Hospital NHS TrustManchesterUK