Mapping of gene loci in the Q13–Q15 region of chromosome 12
- Cite this article as:
- Mitchell, E.L.D., White, G.R.M., Santibanez-Koref, M.F. et al. Chromosome Res (1995) 3: 261. doi:10.1007/BF00713052
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The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13–q15 region of chromosome 12. Using fluorescencein situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3–14.1, CDK4 to 12q14 and MDM2 to 12q14.3–q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.