Immunogenetics

, Volume 31, Issue 1, pp 29–36

The nucleotide sequence of the bovine MHC class II alpha genes:DRA, DQA, andDYA

Authors

  • Jan J. van der Poel
    • Department of Animal BreedingAgricultural University Wageningen
  • Martien A. M. Groenen
    • Department of Animal BreedingAgricultural University Wageningen
  • Rosilde J. M. Dijkhof
    • Department of Animal BreedingAgricultural University Wageningen
  • Dirk Ruyter
    • Department of Animal BreedingAgricultural University Wageningen
  • Marius J. Giphart
    • Department of Animal BreedingAgricultural University Wageningen
    • Department of Immunohaematology and BloodbankUniversity Hospital
Article

DOI: 10.1007/BF00702486

Cite this article as:
van der Poel, J.J., Groenen, M.A.M., Dijkhof, R.J.M. et al. Immunogenetics (1990) 31: 29. doi:10.1007/BF00702486

Abstract

The nucleotide sequence of the exons 2, 3, and 4, and parts of the intervening sequences of aBoLA-DRA and-DQA gene and one other class IIBoLA-A gene have been determined. The structure of theBoLA-DRA and-DQA gene was found to be very similar to that of the corresponding human HLA class II genes. An analysis of the structure of the other class IIBoLA-A gene showed that thisA gene was clearly very different from both the humanA genes and the bovineDRA andDQA genes. The results indicate that this other type of class IIA gene probably represents the class II gene that has already been identified in restriction fragment length polymorphism (RFLP) studies asBoLA-DYA. Since no clear homologue of this presumedBoLA-DYA gene was found among the human HLA class II genes, these results indicate that, at least as far as theA genes are concerned, a distinct class II gene is present in cattle.

Copyright information

© Springer-Verlag 1990