Alterations in the hippocampus of aged mice
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- Lamar, C.H., Hinsman, E.J. & Henrikson, C.K. Acta Neuropathol (1976) 36: 387. doi:10.1007/BF00699644
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The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1–2 μ in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.