Acta Neuropathologica

, Volume 36, Issue 4, pp 387–391

Alterations in the hippocampus of aged mice


  • C. H. Lamar
    • School of Veterinary MedicinePurdue University
  • E. J. Hinsman
    • School of Veterinary MedicinePurdue University
  • C. K. Henrikson
    • School of Veterinary MedicinePurdue University
Short Original Communications

DOI: 10.1007/BF00699644

Cite this article as:
Lamar, C.H., Hinsman, E.J. & Henrikson, C.K. Acta Neuropathol (1976) 36: 387. doi:10.1007/BF00699644


The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1–2 μ in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.

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© Springer-Verlag 1976