Short Original Communications

Acta Neuropathologica

, Volume 36, Issue 4, pp 387-391

First online:

Alterations in the hippocampus of aged mice

  • C. H. LamarAffiliated withSchool of Veterinary Medicine, Purdue University
  • , E. J. HinsmanAffiliated withSchool of Veterinary Medicine, Purdue University
  • , C. K. HenriksonAffiliated withSchool of Veterinary Medicine, Purdue University

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Summary

The hippocampus of C57B1/6 mice was examined histologically and electron microscopically. Male and female mice at 3 and 8 months of age and female mice at 16 months of age were studied. PAS positive foci, containing particles 1–2 μ in diameter, were observed in the hippocampal region of 8 and 16 month old mice. These particles were diastase sensitive. Electron microscopically, in similar mice, a vacuolating change was observed in the cytoplasm of perithelial cells (pericytes) in the same area.

Key words

Aging Hippocampus Pericytes-mice