Original Works

Acta Neuropathologica

, Volume 61, Issue 3, pp 263-269

Marek's disease virus-induced transient paralysis: A comparison of lesions in susceptible and resistant lines of chickens

  • J. N. KornegayAffiliated withDepartment of Veterinary Pathology, College of Veterinary Medicine, University of Georgia
  • , E. J. GorgaczAffiliated withDepartment of Veterinary Pathology, College of Veterinary Medicine, University of Georgia
  • , M. A. ParkerAffiliated withDepartment of Avian Medicine, College of Veterinary Medicine, University of Georgia
  • , J. R. DuncanAffiliated withDepartment of Veterinary Pathology, College of Veterinary Medicine, University of Georgia
  • , L. W. SchiermanAffiliated withDepartment of Avian Medicine, College of Veterinary Medicine, University of Georgia

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Summary

A study was conducted to determine the causative lesion of Marek's disease virus-induced transient paralysis. Brain histologic lesions were quantitated and compared in genetically resistant and susceptible inbred chickens. Comparisons were made 11 days post inoculation (PI) of virus when clinical signs were evident in susceptible birds and on day 17 PI when these signs had remitted. Clinically-affected birds from the susceptible line on day 11 PI had consistent evidence of neuropil vacuolation compatible with brain edema; two of these birds also had vasculitis. These lesions were absent in both clinically-recovered birds from this line evaluated on day 17 PI and genetically resistant birds studied on day 11 PI. Our findings suggest that the causative lesion of transient paralysis is vasogenic brain edema.

Key words

Marek's disease herpesvirus Transient paralysis Neuropil vacuolation Vasogenic brain edema