Acta Neuropathologica

, Volume 49, Issue 2, pp 117–122

Experimental brain tumors by transplacental ENU

Multifactorial study of the latency period
  • D. Schiffer
  • M. T. Giordana
  • A. Mauro
  • G. Racagni
  • F. Bruno
  • S. Pezzotta
  • P. Paoletti
Original Works

DOI: 10.1007/BF00690751

Cite this article as:
Schiffer, D., Giordana, M.T., Mauro, A. et al. Acta Neuropathol (1980) 49: 117. doi:10.1007/BF00690751
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Summary

Experimental cerebral tumors have been induced by transplacental ENU. The morphologic study of the brains of treated rats revealed that cellular hyperplasias appear at the 30th day of extrauterine life in the paraventricular white matter, i.e., before the already known “early neoplastic proliferations”. Cytofluorimetric investigations failed to demonstrate differences between treated and control rats during the 1st month. On the contrary, adenylate cyclase activity is very high in that period. The duration of the latency period is discussed.

Key words

ENU tumorsLatency period

Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • D. Schiffer
    • 1
  • M. T. Giordana
    • 1
  • A. Mauro
    • 1
  • G. Racagni
    • 2
  • F. Bruno
    • 2
  • S. Pezzotta
    • 3
  • P. Paoletti
    • 3
  1. 1.II. Neurological ClinicUniversity of TurinTurinItaly
  2. 2.Institute of Pharmacology and PharmacognosyUniversity of MilanMilanItaly
  3. 3.Neurosurgical ClinicUniversity of PaviaPaviaItaly