Journal of comparative physiology

, Volume 152, Issue 1, pp 67–72

Adrenergic regulation of haemoglobin oxygen affinity in rainbow trout red cells

  • Mikko Nikinmaa
Article

DOI: 10.1007/BF00689729

Cite this article as:
Nikinmaa, M. J Comp Physiol B (1983) 152: 67. doi:10.1007/BF00689729

Summary

Adrenaline (initial concentration 5×10−6 M) caused an increase in haemoglobin oxygen affinity of rainbow trout red cells incubated in vitro in physiological saline. The increase was more pronounced at low than at high extracellular pH values. Adrenaline also induced an increase in intracellular pH, swelling of red cells and a metabolic decrease in cellular ATP concentration. The most important reason for increased oxygen affinity was the increase in intracellular pH resulting, to a great extent, from decreased concentration of impermeable polyanions, ATP and haemoglobin, in the cell. In addition, the decrease in cellular ATP concentration as such increases oxygen affinity of haemoglobin.

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Mikko Nikinmaa
    • 2
  1. 1.Division of Physiology, Department of ZoologyUniversity of HelsinkiHelsinki 10Finland
  2. 2.Department of ChemistryStanford UniversityStanfordUSA