Taxol encapsulation in poly(ɛ-caprolactone) microspheres
- Cite this article as:
- Dordunoo, S.K., Jackson, J.K., Arsenault, L.A. et al. Cancer Chemother. Pharmacol. (1995) 36: 279. doi:10.1007/BF00689043
Poly(ɛ-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.