Acta Neuropathologica

, Volume 34, Issue 3, pp 183–197

Ultrastructure of Lewy bodies in the stellate ganglion

Authors

  • Lysia S. Forno
    • Laboratory ServicePalo Alto Veterans Administration Hospital
    • Depatment of PathologyStanford University School of Medicine
    • Neuropathology Laboratory 127AVeterans Administration Hospital
  • Roxana L. Norville
    • Laboratory ServicePalo Alto Veterans Administration Hospital
    • Depatment of PathologyStanford University School of Medicine
Original Investigations

DOI: 10.1007/BF00688674

Cite this article as:
Forno, L.S. & Norville, R.L. Acta Neuropathol (1976) 34: 183. doi:10.1007/BF00688674

Summary

The Lewy body, a characteristic nerve cell inclusion in idiopathic parkinsonism, was examined by electron microscopy in the stellate ganglion, obtained from 9 patients at autopsy. Three main forms of Lewy bodies or Lewy body-related structures were demonstrated: A. Rare filamentous Lewy bodies, similar to Lewy bodies in the central nervous system. B. Granular Lewy bodies in nerve cell processes. C. Abnormal nerve cell processes, filled with heterogenous material. Large dense core vesicles were prominent in the last 2 forms. None of these abnormalities were found in 2 control groups consisting of 9 parkinsonism cases without central nervous system Lewy bodies, and 17 cases without parkinsonism.

The filamentous Lewy body (type A) was found in the perikaryon and was surrounded by neuromelanin, whereas the other forms (type B and C) were seen in nerve cell processes.

Mitochondrial inclusions, present mainly, but not exclusively, in neuromelanin-containing cells, were not related to Lewy body formation or to parkinsonism.

Key words

Lewy bodyElectron microscopyParkinsonismDense core vesiclesCatecholaminesMitochondrial inclusions

Copyright information

© Springer-Verlag 1976