Acta Neuropathologica

, Volume 58, Issue 4, pp 255–260

The Onuf's nucleus and the external anal sphincter muscles in amyotrophic lateral sclerosis and Shy-Drager syndrome

Authors

  • T. Mannen
    • Dept. of Neurology, Institute of Brain Research, Faculty of MedicineUniversity of Tokyo
  • M. Iwata
    • Dept. of Neurology, Institute of Brain Research, Faculty of MedicineUniversity of Tokyo
  • Y. Toyokura
    • Dept. of Neurology, Institute of Brain Research, Faculty of MedicineUniversity of Tokyo
  • K. Nagashima
    • Department of Pathology, Faculty of MedicineUniversity of Tokyo
Original Works

DOI: 10.1007/BF00688606

Cite this article as:
Mannen, T., Iwata, M., Toyokura, Y. et al. Acta Neuropathol (1982) 58: 255. doi:10.1007/BF00688606

Summary

The anterior sacral horns and external anal sphincter muscle were examined histologically with special reference to Onuf's nucleus in amyotrophic lateral sclerosis (ALS) and Shy-Drager syndrome. Onuf's nucleus and the external anal sphincter muscles were well preserved in ALS, but in Shy-Drager syndrome both structures showed marked degenerative changes. These findings suggest that Onuf's nucleus does not belong to the autonomic neurons, but to the motoneurons in anterior sacral horn, and it innervates the external sphincter muscles of the anus and urethra.

Key words

Onuf's nucleusSphincter musclesALSShy-Drager syndrome

Copyright information

© Springer-Verlag 1982