Acta Neuropathologica

, Volume 76, Issue 3, pp 222–226

Abnormal neuronal distribution within the cerebral cortex after prenatal methylmercury intoxication

  • N. H. Peckham
  • B. H. Choi
Regular Papers

DOI: 10.1007/BF00687768

Cite this article as:
Peckham, N.H. & Choi, B.H. Acta Neuropathol (1988) 76: 222. doi:10.1007/BF00687768

Summary

C57BL/6J mice were poisoned with methylmercury during pregnancy, and the location of heavily labeled neurons generated at embryonic day 16 was determined by tritiated thymidine autoradiography of the cerebral cortex of offspring at postnatal day 10. Camera lucida plotting of the distribution of radioactively labeled cortical neurons revealed statistically significant differences between control and methylmercury-treated groups. While control animals showed regular and tight packing of labeled neurons within the upper part of the cortical layer II, in methylmercury-treated animals such neurons were irregularly distributed throughout cortical layers II and III. Short-term intermittent and long-term lowdosage regimens of intoxication produced similar results. These findings support the hypothesis that prenatal methylmercury poisoning results in abnormal neuronal migration and anomalous cortical cytoarchitectonic patterning within the developing brain and provide a possible morphological basis for some of the neurobehavioral abnormalities that may be observed in association with sublethal prenatal intoxication in humans.

Key words

MethylmercuryBrain developmentNeuronal migrationAutoradiography

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • N. H. Peckham
    • 1
  • B. H. Choi
    • 2
  1. 1.Department of PathologyLoma Linda University School of MedicineLoma LindaUSA
  2. 2.Division of Neuropathology, Department of PathologyUniversity of California IrvineIrvineUSA