, Volume 74, Issue 4, pp 397-401

Neuropathology of Seckel syndrome in fetal stage with evidence of intrauterine developmental retardation

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Marked intrauterine developmental retardation in a fetal case of Seckel syndrome was morphologically defined in the 29th week of gestation by comparing with a large number of length-matched and age-matched controls. Telencephalic micrencephaly with reduced neuroblast production, retarded functional differentiation of the pituitary gland, and generalized hypotrophy with craniofacial stigmata were observed.