Acta Neuropathologica

, Volume 74, Issue 4, pp 397–401

Neuropathology of Seckel syndrome in fetal stage with evidence of intrauterine developmental retardation

  • A. Hori
  • K. Tamagawa
  • S. W. Eber
  • M. Westmeier
  • I. Hansmann
Case reports

DOI: 10.1007/BF00687219

Cite this article as:
Hori, A., Tamagawa, K., Eber, S.W. et al. Acta Neuropathol (1987) 74: 397. doi:10.1007/BF00687219

Summary

Marked intrauterine developmental retardation in a fetal case of Seckel syndrome was morphologically defined in the 29th week of gestation by comparing with a large number of length-matched and age-matched controls. Telencephalic micrencephaly with reduced neuroblast production, retarded functional differentiation of the pituitary gland, and generalized hypotrophy with craniofacial stigmata were observed.

Key words

Fetal brain developmentImmunohistochemistryIntrauterine growth retardationMicrocephalySeckel syndrome

Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Hori
    • 1
  • K. Tamagawa
    • 1
  • S. W. Eber
    • 2
  • M. Westmeier
    • 2
  • I. Hansmann
    • 3
  1. 1.Department of NeuropathologyUniversität GöttingenGöttingenGermany
  2. 2.Department of PediatricsUniversität GöttingenGöttingenGermany
  3. 3.Department of Human GeneticsUniversität GöttingenGöttingenGermany