Acta Neuropathologica

, Volume 75, Issue 5, pp 513–518

Quantitative study of lateral horn cells in 15 cases of multiple system atrophy

  • F. Gray
  • D. Vincent
  • J. J. Hauw
Regular Papers

DOI: 10.1007/BF00687140

Cite this article as:
Gray, F., Vincent, D. & Hauw, J.J. Acta Neuropathol (1988) 75: 513. doi:10.1007/BF00687140


Nerve cell counts of the lateral horns of the spinal cord were performed in 15 cases of multiple system atrophy (MSA) and three age-and sexmatched controls. The patients with MSA were comprised of eight with severe postural hypotension, three with orthostatic hypotension and little or no disability and four without any signs of autonomic failure. All cases of MSA had lost more than half their lateral horn cells but nerve cell loss could not be correlated with the degree of dysautonomia. These results confirm the involvement of the intermediolateral columns of the spinal cord in MSA. However, the lack of correlation between cell loss and severity of autonomic failure in our cases, suggests that lesions of other sites, such as sympathetic ganglia or the dorsal vagal nuclei, are also implicated in dysautonomia.

Key words

Cell countsDysautonomiaLateral horn of the spinal cordMultiple system atrophy

Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • F. Gray
    • 1
    • 2
  • D. Vincent
    • 3
  • J. J. Hauw
    • 3
  1. 1.Départment de Pathologie (Neuropathologie)Hôpital Henri MondorCréteil CedexFrance
  2. 2.Départment Universitaire d'Enseignement et de Recherche en Neurosciences, Faculté de MédecineUniversité Paris-Val de MarneParisFrance
  3. 3.Laboratoire de Neuropathologie Raymond EscourolleParisFrance