Cancer Chemotherapy and Pharmacology

, Volume 33, Supplement 1, pp S103–S108

Outcomes of 116 patients with hepatocellular carcinoma

  • Hiroyoshi Onodera
  • Katsuaki Ukai
  • Noboru Nakano
  • Tetsutaro Takeda
  • Hiroshi Suzuki
  • Toshiki Okata
  • Tadashi Motojima
  • Ichiro Kuwashima
  • Shigenori Ujiie
  • Tadami Shoji
Clinical Aspects in the Treatment for Operable and Session II. Chemotherapy and Radiotherapy II. 1. TAE-2 Hepatocellular Carcinoma, Interventional Radiology

DOI: 10.1007/BF00686678

Cite this article as:
Onodera, H., Ukai, K., Nakano, N. et al. Cancer Chemother. Pharmacol. (1994) 33: S103. doi:10.1007/BF00686678

Abstract

We studied the outcomes of 116 patients with hepatocellular carcinoma (HCC) diagnosed in our hospital between January 1980 and August 1992. The patients were divided into groups according to the principal treatment procedure. The 3-year survival rates in the patients treated by percutaneous ultrasonically guided ethanol injection (PEI), operation (hepatic resection), and transcatheter hepatic arterial embolization (TAE) were 90.9%, 53.6%, and 29.0%, respectively. None of the patients treated by oneshot injection of an anticancer agent into the hepatic artery and chemotherapy survived for more than 2 years. The outcomes of the patients treated by PEI and hepatic resection were significantly better than those of the patients treated by the other procedures. There was no significant difference when the patients were stratified according to the year of detection. The 3-year survival rate was 57.3% for 19 patients in whom HCCs were detected during clinical follow-up for chronic liver disease and 17.3% for the other 97 patients. We concluded that hepatic resection in patients with good liver function and PEI for early HCC yielded significantly better survival rates than the other procedures. Moreover, for early detection and treatment of HCC, we recommend clinical follow-up of patients with chronic liver disease.

Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Hiroyoshi Onodera
    • 1
  • Katsuaki Ukai
    • 1
  • Noboru Nakano
    • 1
  • Tetsutaro Takeda
    • 1
  • Hiroshi Suzuki
    • 1
  • Toshiki Okata
    • 1
  • Tadashi Motojima
    • 1
  • Ichiro Kuwashima
    • 1
  • Shigenori Ujiie
    • 1
  • Tadami Shoji
    • 1
  1. 1.Department of Internal MedicineMiyagi Cancer Center HospitalNatori, Miyagi PrefectureJapan