Acta Neuropathologica

, Volume 36, Issue 3, pp 221–233

Presenile dementia with Alzheimer-, Pick- and Lewy-body changes

Authors

  • Kenji Kosaka
    • Division of NeuropathologyPsychiatric Research Institute of Tokyo
  • Shinsaku Oyanagi
    • Division of NeuropathologyPsychiatric Research Institute of Tokyo
  • Masaaki Matsushita
    • Division of NeuropathologyPsychiatric Research Institute of Tokyo
  • Akira Hori
    • Division of NeuropathologyPsychiatric Research Institute of Tokyo
  • Shoji Iwase
    • Moriyamaso Hospital
Original Investigations

DOI: 10.1007/BF00685366

Cite this article as:
Kosaka, K., Oyanagi, S., Matsushita, M. et al. Acta Neuropathol (1976) 36: 221. doi:10.1007/BF00685366

Summary

An autopsy case of unclassifiable presenile dementia is reported. The outstanding pathological findings were as follows;
  1. 1.

    presence of senile plaques, neurofibrillary changes, Pick bodies, Hirano bodies, granulovacuolar degeneration of neurons, etc.

     
  2. 2.

    numerous Lewy bodies in the brain stem and diencephalon,

     
  3. 3.

    peculiar swollen neurons with intracytoplasmic, eosinophilic and argentophilic inclusions (“Lewy-like-bodies”) in the cerebral cortices.

     

Detailed study of the last mentioned inclusions indicates that they are almost identical to Lewy bodies, though there are some minor differences, in histochemical and electronmicroscopic findings.

Nosologically, this case may represent either a combination of Alzheimer's disease, Pick's disease and idiopathic Parkinsonism with “Lewy-like-bodies” in the cerebral cortices, or a single disease.

As far as we know, no similar case been reported.

Key words

Lewy bodyIdiopathic ParkinsonismAlzheimer's diseasePick's diseaseUnclassifiable presenile dementia

Copyright information

© Springer-Verlag 1976