European Journal of Clinical Pharmacology

, Volume 37, Issue 3, pp 267–272

The pharmacokinetics of midazolam in paediatric patients

  • K. Payne
  • F. J. Mattheyse
  • D. Liebenberg
  • T. Dawes

DOI: 10.1007/BF00679782

Cite this article as:
Payne, K., Mattheyse, F.J., Liebenberg, D. et al. Eur J Clin Pharmacol (1989) 37: 267. doi:10.1007/BF00679782


A serum concentration profile study on midazolam in children was done. Fifty six children aged 3–10 years took part. The routes investigated were intravenous, intramuscular, rectal and oral at 0.15 mg·kg−1, and the oral at 0.45 mg·kg−1 and 1 mg·kg−1. Serum concentration levels for 5 h were studied using gas liquid chromatography.

The volume of distribution, Vss, was 1.29 l·kg−1, the elimination half-life 1.17 h and the serum clearance 9.11 ml·kg−1·min−1. Peak serum concentrations for the intramuscular, rectal and oral routes were at 15 min, 30 min and 53 min respectively. Bioavailability was 87%, 18%, 27% respectively at a dose of 0.15 mg·kg−1. The oral route bioavailability halved to 15% at the two higher doses.

Bioequivalence was present between the 0.15 mg·kg−1 intramuscular dose and the 0.45 mg·kg−1 oral dose from 45 to 120 min.

Key words

midazolam pharmacokinetics children 

Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • K. Payne
    • 1
  • F. J. Mattheyse
    • 2
  • D. Liebenberg
    • 3
  • T. Dawes
    • 4
  1. 1.Department of AnaesthesiaUniversity of StellenboschParowvallei, TygerbergSouth Africa
  2. 2.Department of PhysiologyUniversity of StellenboschParowvallei, TygerbergSouth Africa
  3. 3.Department of Pharmacology, Medical SchoolUniversity of StellenboschParowvallei, TygerbergSouth Africa
  4. 4.Tygerberg HospitalParowvallei, TygerbergSouth Africa

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