Breast Cancer Research and Treatment

, Volume 26, Issue 1, pp S19–S23

New strategies in marrow purging for breast cancer patients receiving high-dose chemotherapy with autologous bone marrow transplantation

  • Elizabeth J. Shpall
  • Salomon M. Stemmer
  • Scott I. Bearman
  • Susan Myers
  • Malcolm Purdy
  • Roy B. Jones
Dose-intensive therapy — applications in breast cancer (Mini-symposium)

DOI: 10.1007/BF00668356

Cite this article as:
Shpall, E.J., Stemmer, S.M., Bearman, S.I. et al. Breast Cancer Res Tr (1993) 26: S19. doi:10.1007/BF00668356

Summary

High-dose chemotherapy and autologous bone marrow transplantation (ABMT) are commonly used to treat selected patients with high-risk breast cancer. A limitation of ABMT is that clonogenic cancer cells could be collected with the bone marrow and produce a relapse of disease when reinfused into patients. Purging the marrowex vivo may eliminate the tumor cells, but it can also delay engraftment. We employed two different purging methods whereby breast cancer cells were depleted without delaying engraftment. The addition of WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) reduced the time to engraftment by 10 days compared with marrow purged with 4-HC alone (26 versus 37 days, respectively). The positive selection of CD34+ hematopoietic progenitors produced engraftment within 21 days. The use of granulocyte colony-stimulating factor (G-CSF) accelerated the engraftment time of CD34+ hematopoietic progenitors to 11 days.

Key words

amifostine autologous bone marrow transplantation (ABMT) breast cancer 4-hydroperoxycyclophoshamide (4-HC) marrow purging 

Copyright information

© Kluwer Academic Publishers 1993

Authors and Affiliations

  • Elizabeth J. Shpall
    • 1
  • Salomon M. Stemmer
    • 1
  • Scott I. Bearman
    • 1
  • Susan Myers
    • 1
  • Malcolm Purdy
    • 1
  • Roy B. Jones
    • 1
  1. 1.University of Colorado Bone Marrow Transplant ProgramUniversity of Colorado Health Sciences CenterDenverUSA

Personalised recommendations