Breast Cancer Research and Treatment

, Volume 32, Issue 1, pp 67–71

Heat shock proteins and drug resistance

  • Suzanne A. W. Fuqua
  • Steffi Oesterreich
  • Susan G. Hilsenbeck
  • Daniel D. Von Hoff
  • John Eckardt
  • C. Kent Osborne
Article

DOI: 10.1007/BF00666207

Cite this article as:
Fuqua, S.A.W., Oesterreich, S., Hilsenbeck, S.G. et al. Breast Cancer Res Tr (1994) 32: 67. doi:10.1007/BF00666207

Summary

Heat shock proteins (hsp's) are induced in cells when exposed to different environmental stressful conditions. We have found that breast cancer cells sometimes express high levels of several hsp's, which may both augment the aggressiveness of these tumors and make them more resistant to treatment. We have shown that hsp70 is an ominous prognostic sign as detected by Western blot assays in node-negative breast tumors, and that hsp27 increases specific resistance to doxorubicin in breast cancer cell lines. These findings have direct clinical application, and suggest that modulating hsp expression may be a therapeutic target for reversal of hsp-associated detrimental cellular effects.

Key words

doxorubicin drug resistance heat shock hsp27 hsp70 prognosis stress response 

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Suzanne A. W. Fuqua
    • 1
  • Steffi Oesterreich
    • 1
  • Susan G. Hilsenbeck
    • 1
  • Daniel D. Von Hoff
    • 2
  • John Eckardt
    • 2
  • C. Kent Osborne
    • 1
  1. 1.Department of Medicine, Division of Medical OncologyUniversity of Texas Health Science CenterSan AntonioUSA
  2. 2.Cancer Therapy and Research CenterSan AntonioUSA