Cancer and Metastasis Reviews

, Volume 13, Issue 3, pp 411–431

Regulation of protein kinase C and role in cancer biology

  • Gerard C. Blobe
  • Lina M. Obeid
  • Yusuf A. Hannun
Article

DOI: 10.1007/BF00666107

Cite this article as:
Blobe, G.C., Obeid, L.M. & Hannun, Y.A. Cancer Metast Rev (1994) 13: 411. doi:10.1007/BF00666107

Abstract

Protein kinase C (PKC) is a family of closely related lipid-dependent and diacyglycerol-activated isoenzymes known to play an important role in the signal transduction pathways involved in hormone release, mitogenesis and tumor promotion. Reversible activation of PKC by the second messengers diacylglycerol and calcium is an established model for the short term regulation of PKC in the immediate events of signal transduction. PKC can also be modulated long term by changes in the levels of activators or inhibitors for a prolonged period or by changes in the levels of functional PKC isoenzymes in the cell during development or in response to hormones and/or differentiation factors. Indeed, studies have indicated that the sustained activation or inhibition of PKC activityin vivo may play a critical role in regulation of long term cellular events such as proliferation, differentiation and tumorigenesis. In addition, these regulatory events are important in colon cancer, where a decrease in PKC activators and activity suggests PKC acts as an anti-oncogene, in breast cancer, where an increase in PKC activity suggests an oncogenic role for PKC, and in multidrug resistance (MDR) and metastasis where an increase in PKC activity correlates with increased resistance and metastatic potential. These studies highlight the importance and significance of regulation of PKC activityin vivo.

Key words

protein kinase C isoenzymes cancer differentiation 

Copyright information

© Kluwer Academic Publishers 1994

Authors and Affiliations

  • Gerard C. Blobe
    • 1
  • Lina M. Obeid
    • 1
  • Yusuf A. Hannun
    • 1
  1. 1.Divisions of Hematology/Oncology and Geriatrics, Departments of Medicine and Cell BiologyDuke University Medical CenterDurhamUSA

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